GO:0086024 biological_process adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate
| PAG Title | GO:0086024 biological_process adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate |
| PAG ID | TAX030219 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate. |
| Species | Homo sapiens |
| nCoCo Score | 0 |
| Base PAG ID | TAX030219 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
">
Something else? Please send us an email!